Acclimate
Acclimatization is the only tried and true way for anyone to prevent or mitigate the symptoms of altitude sickness. If it’s at all possible, or you know you’re susceptible to altitude sickness, consider spending an afternoon and night at a lower altitue, perhaps 3,000ft-5,000ft in the mountains. Even just this 12 to 24-hour period could help tremendously.
Hydrate
Yes, hydrate, but going overboard isn’t actually necessary, either, according to the Institute for Altitude Medicine (IAM). Rather than slamming several liters more per day, simply be aware of your intake, and consider adding 1 to 1.5 liters (a typical Nalgene bottle is one liter) per day while at altitude. Adding this to your daily water intake in the days before you travel can’t hurt, either.
Watch your alcohol
Alcohol is a diuretic, so any symptom that comes with dehydration (headache, rapid heart rate, nausea), could be exacerbated by elevation. This is true, and a good enough reason to just be aware of your body if you’re consuming alcohol at high altitudes. However, what’s not true is that you’ll become intoxicated faster at high altitude. Though often perpetuated by tourists in bars, several studies have determined the effects of alcohol are not more pronounced at higher altitudes. In reality, the mere fact of being at 12,000 feet, one study showed, was enough to slightly impair participants who hadn’t even had a drop to drink.
Bottom line: Be smart and responsible and drink water as well, just as you would any other time you’re consuming alcohol, and you shouldn’t have a problem.
Also note: The myth about drinking caffeine at elevation is similar. IAM states that it would require enormous amounts of caffeine from coffee and soda to cause adverse effects at altitude. Moreover, if you’re used to drinking 2-3 cups of coffee a day, cutting cold turkey could actually cause more problems. Everything in moderation.
Diamox
If you know you’re susceptible to altitude sickness, you could consider taking the drug Diamox (Acetazolamide). Please be aware this drug isn’t used to treat symptoms of altitude sickness, in the way Tylenol could temporarily help with the pain of a headache, but rather it helps the body with the acclimatization process. Experts recommend starting Diamox 24 hours before arriving in Telluride, and continuing its use for 48 hours while in the destination.